Science

Published Papers

2024

• Cleanthis Michael, Mackenzie E. Mitchell, Arianna D. Cascone, Nicholas D. Fogelman, Keri S. Rosch, Sarah A. Cutts, James J. Pekar, Olaf Sporns, Stewart H. Mostofsky, and Jessica R. Cohen. (2024) "Reconfiguration of functional brain network organization and dynamics with changing cognitive demands in children with attention-deficit/hyperactivity disorder." Biol Psychiatry Cogn Neurosci Imaging
  
  
  Abstract

  The pathophysiology of attention-deficit/hyperactivity disorder (ADHD) is characterized by atypical brain network organization and dynamics. Although functional brain networks adaptively reconfigure across cognitive contexts, previous studies have largely focused on network dysfunction during the resting-state. This preliminary study examined how functional brain network organization and dynamics flexibly reconfigure across rest and two cognitive control tasks with different cognitive demands in 30 children with ADHD and 36 typically developing (TD) children (8-12 years).
  PubMed Published

2023

• Arianna D. Cascone, Finnegan Calabro, William Foran, Bart Larsen, Tehila Nugiel, Ashley C. Parr, Brenden Tervo-Clemmens, Beatriz Luna, and Jessica R. Cohen. (2023) "Brain tissue iron neurophysiology and its relationship with the cognitive effects of dopaminergic modulation in children with and without ADHD." Developmental Cognitive Neuroscience
  
  
  Abstract

  Children with attention-deficit/hyperactivity disorder (ADHD) exhibit impairments in response inhibition. These impairments are ameliorated by modulating dopamine (DA) via the administration of rewards or stimulant medication like methylphenidate (MPH). It is currently unclear whether intrinsic DA availability impacts these effects of dopaminergic modulation on response inhibition. Thus, we estimated intrinsic DA availability using magnetic resonance-based assessments of basal ganglia and thalamic tissue iron in 36 medication-naïve children with ADHD and 29 typically developing (TD) children (8–12 y) who underwent fMRI scans and completed standard and rewarded go/no-go tasks. Children with ADHD additionally participated in a double-blind, randomized, placebo-controlled, crossover MPH challenge. Using linear regressions covarying for age and sex, we determined there were no group differences in brain tissue iron. We additionally found that higher putamen tissue iron was associated with worse response inhibition performance in all participants. Crucially, we observed that higher putamen and caudate tissue iron was associated with greater responsivity to MPH, as measured by improved task performance, in participants with ADHD. These results begin to clarify the role of subcortical brain tissue iron, a measure associated with intrinsic DA availability, in the cognitive effects of reward- and MPH-related dopaminergic modulation in children with ADHD and TD children.
  PubMed Published

2021

• Arianna D. Cascone, Stephanie Langella, Miriam Sklerov, and Eran Dayan. (2021) "Frontoparietal network resilience is associated with protection against cognitive decline in Parkinson's disease." Communications Biology
  
  
  Abstract

  Though Parkinson's disease is primarily defined as a movement disorder, it is also characterized by a range of non-motor symptoms, including cognitive decline. The onset and progression of cognitive decline in individuals with Parkinson's disease is variable, and the neurobiological mechanisms that contribute to, or protect against, cognitive decline in Parkinson's disease are poorly understood. Using resting-state functional magnetic resonance imaging data collected from individuals with Parkinson's disease with and without cognitive decline, we examined the relationship between topological brain-network resilience and cognition in Parkinson's disease. By leveraging network attack analyses, we demonstrate that relative to individuals with Parkinson's disease experiencing cognitive decline, the frontoparietal network in cognitively stable individuals with Parkinson's disease is significantly more resilient to network perturbation. Our findings suggest that the topological robustness of the frontoparietal network is associated with the absence of cognitive decline in individuals with Parkinson's disease.
  PubMed Published

Fellowships

Categorical and dimensional investigations of dynamic functional connectivity and behavior during response inhibition in children with and without ADHD

1F31MH130152-01A1, Cascone (PI)
Role: Principal Investigator (100% effort)
Agency: National Institute of Mental Health, NIH

January 2023 – January 2026  Direct costs: $114,657

Published Abstracts

Cascone, A., Giannuzzi, A., Srinivasan, J., Wissemann, K., Taddeo, M., Fafard, L., Bumstead, B., Zarif, M., Buhse, M., Gudesblatt, M. (2018). Multiple sclerosis, fatigue, and disease-modifying therapy impact: Differences in sleep architecture in patients with multiple sclerosis – copaxone versus interferons. Multiple Sclerosis Journal, 24(S2), 324. https://doi.org/10.1177/1352458518798582

Cascone, A., Giannuzzi, A., Srinivasan, J., Wissemann, K., Taddeo, M., Fafard, L., Bumstead, B., Zarif, M., Buhse, M., Gudesblatt, M. (2018). The relationship between obstructive sleep apnea and age, gender, EDSS, disease duration, and BMI in people with multiple sclerosis who report fatigue: More than size matters. Multiple Sclerosis Journal, 24(S2), 566. https://doi.org/10.1177/1352458518798591

Giannuzzi, A., Srinivasan, J., Cascone, A., Wissemann, K., Taddeo, M., Fafard, L., Bumstead, B., Zarif, M., Buhse, M., Gudesblatt, M. (2018). Central sleep apnea in people with multiple sclerosis who report fatigue: Polysomnography study in a large cohort. Multiple Sclerosis Journal, 24(S2), 364. https://doi.org/10.1177/1352458518798590 

Giannuzzi, A., Srinivasan, J., Cascone, A., Wissemann, K., Taddeo, M., Fafard, L., Bumstead, B., Zarif, M., Buhse, M., Gudesblatt, M. (2018). Fatigue, patient reported outcomes, and sleep apnea in people with multiple sclerosis: Perception is insufficient to just sleep on it. Multiple Sclerosis Journal, 24(S2), 796. https://doi.org/10.1177/1352458518798592 

Srinivasan, J., Giannuzzi, A., Cascone, A., Wissemann, K., Taddeo, M., Fafard, L., Bumstead, B., Zarif, M., Gudesblatt, M. (2018). Periodic limb movements in people with multiple sclerosis who report fatigue: Polysomnography study in a large cohort. Multiple Sclerosis Journal, 24(S2), 154. https://doi.org/10.1177/1352458518798582